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Protein backbone design with RFDiffusion NIM v1.0.0

Use this resource to design protein backbones with RFDiffusion NIM

New

  • 537 downloads
  • 113 likes
  • 215 saves

Free

Install with the CLI

In a terminal, from the folder you want:

npx --yes palatekit@latest install rfdiffusion-protein-backbone-design

With no option, the skill goes to ~/.agents/skills/; add --agent claude-code (or codex, cursor…) to target an agent.

First time: connect the CLI with

npx --yes palatekit@latest login

The agent picks hosted or local mode, builds the contigs syntax and target residues, then runs generation. You get backbone PDB files, ready for sequence design with ProteinMPNN.

Mostly picked by

Updated November 2, 2026

Card for the “Protein backbone design with RFDiffusion NIM” skill

Details

Works in
Install guides
Generates with
Your agent's model
Licence
CC-BY-4.0

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What you get

  • references/parameters.md: contigs, target residues and diffusion steps
  • references/api.md: endpoints and schemas
  • references/validation.md: PDB and contig checks

Good fit for

  • You want a protein binder around a target residue
  • You look for de novo backbones to design sequences for later

Not for

    Tags

    • rfdiffusion
    • protein design
    • backbone
    • nim

    About

    You say

    “Generate binder backbones around this target residue with RFDiffusion NIM.”

    Card for the “Protein backbone design with RFDiffusion NIM” skill

    Skill published by nvidia under the CC-BY-4.0 license, delivered in its original version.

    Show more

    How to use it

    1. Install the skill in your agent's skills folder
    2. Ask your agent to design protein backbones with RFDiffusion NIM
    3. Review and adjust the result

    Content preview

    Files

    • BENCHMARK.md7.1 KB
    • config/skillspector-baseline.yml0.9 KB
    • evals/config.yml0.1 KB
    • evals/evals.json6.9 KB
    • evals/trigger_evals.json2.2 KB
    • LICENSE11.3 KB
    • NOTICE-PALATEKIT.md0.5 KB
    • references/api.md3.7 KB
    • references/examples.md0.9 KB
    • references/parameters.md0.4 KB
    • references/science.md1 KB
    • references/validation.md0.7 KB
    • skill-card.md4.1 KB
    • SKILL.md5.4 KB
    • skill.oms.sig6.3 KB

    Origin and licence

    Listed unmodified

    Author
    nvidia
    Source
    github.com/nvidia/skills/tree/ca116d60beafe1b4459f0ab790b7b450912c56b0/skills/bionemo-rfdiffusion-nim
    Licence
    CC-BY-4.0

    Notice

    « rfdiffusion-nim » (nvidia, CC-BY-4.0) livré dans sa version d'origine : fiche en français et en anglais par PalateKit.

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