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Clinical variant interpretation and ACMG classification v1.0.0
Use this resource to classify a variant under ACMG and write a clinical report
New
- 588 downloads
- 138 likes
- 231 saves
Free
Install with the CLI
In a terminal, from the folder you want:
npx --yes palatekit@latest install clinical-variant-interpretationWith no option, the skill goes to ~/.agents/skills/; add --agent claude-code (or codex, cursor…) to target an agent.
First time: connect the CLI with
npx --yes palatekit@latest loginThe agent identifies the variant, queries clinical databases and predictors, analyzes the structural impact of missense variants and predicts the effect of non-coding variants. It produces a report citing the ACMG criteria.
Mostly picked by
Updated November 2, 2026
Previews
Details
- Install guides
- Generates with
- Your agent's model
- Licence
- Apache-2.0
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What you get
- ACMG_CLASSIFICATION.md: ACMG classification guide
- CHECKLIST.md: checklist
- SKILL.md: identity, clinical database and prediction phases
Good fit for
- You must resolve a VUS for a results report
- You want the effect of a variant in a promoter or intron
Not for
Tags
- variant
- ACMG
- VUS
- clinical report
About
You say
“Classify this variant under ACMG and explain the criteria used.”
Skill published by mims-harvard under the Apache-2.0 license, delivered in its original version.
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How to use it
- Install the skill in your agent's skills folder
- Ask your agent to classify a variant under ACMG and write a clinical report
- Review and adjust the result
Content preview
Files
- ACMG_CLASSIFICATION.md6.2 KB
- CHECKLIST.md8.5 KB
- CODE_PATTERNS.md14.4 KB
- EXAMPLES.md18.3 KB
- LICENSE11.1 KB
- NOTICE-PALATEKIT.md0.5 KB
- SKILL.md25.5 KB
- TOOLS_REFERENCE.md39.4 KB
Origin and licence
Listed unmodified
- Author
- mims-harvard
- Source
- github.com/mims-harvard/tooluniverse/tree/169d065deeb3e289b3ff36d665529a123bdad791/skills/tooluniverse-variant-interpretation
- Licence
- Apache-2.0
Notice
« tooluniverse-variant-interpretation » (mims-harvard, Apache-2.0) livré dans sa version d'origine : fiche en français et en anglais par PalateKit.
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