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Loss-of-function mechanism of a missense variant v1.0.0
Use this resource to explain the mechanism by which a missense variant loses function
New
- 550 downloads
- 136 likes
- 111 saves
Free
Install with the CLI
In a terminal, from the folder you want:
npx --yes palatekit@latest install missense-loss-of-function-mechanismWith no option, the skill goes to ~/.agents/skills/; add --agent claude-code (or codex, cursor…) to target an agent.
First time: connect the CLI with
npx --yes palatekit@latest loginThe agent combines pathogenicity, structural context, sequence plausibility, feature disruption and stability, then distinguishes loss of function through misfolding from direct damage to a functional site.
Mostly picked by
Updated November 2, 2026
Previews
Details
- Install guides
- Generates with
- Your agent's model
- Licence
- Apache-2.0
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What you get
- SKILL.md: prerequisites, inputs and steps 0 to 5
- SKILL.md: rules for synthesizing the mechanism
Good fit for
- A missense variant is judged damaging and you want the mechanism
- You want to know whether a variant destabilizes the protein or hits its active site
Not for
Tags
- missense
- loss of function
- mechanism
- stability
About
You say
“Why is this TP53 missense variant loss-of-function?”
Skill published by mims-harvard under the Apache-2.0 license, delivered in its original version.
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How to use it
- Install the skill in your agent's skills folder
- Ask your agent to explain the mechanism by which a missense variant loses function
- Review and adjust the result
Content preview
Files
- LICENSE11.1 KB
- NOTICE-PALATEKIT.md0.5 KB
- SKILL.md13.2 KB
Origin and licence
Listed unmodified
- Author
- mims-harvard
- Source
- github.com/mims-harvard/tooluniverse/tree/169d065deeb3e289b3ff36d665529a123bdad791/skills/tooluniverse-protein-lof-mechanism
- Licence
- Apache-2.0
Notice
« tooluniverse-protein-lof-mechanism » (mims-harvard, Apache-2.0) livré dans sa version d'origine : fiche en français et en anglais par PalateKit.
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