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De novo therapeutic protein design v1.0.0
Use this resource to design a binder or therapeutic protein de novo
New
- 326 downloads
- 220 likes
- 218 saves
Free
Install with the CLI
In a terminal, from the folder you want:
npx --yes palatekit@latest install protein-binder-design-pipelineWith no option, the skill goes to ~/.agents/skills/; add --agent claude-code (or codex, cursor…) to target an agent.
First time: connect the CLI with
npx --yes palatekit@latest loginThe agent produces the backbone, designs the sequence and predicts the structure to validate each design, then writes the design record. It keeps folding, pose and geometry evidence separate.
Mostly picked by
Updated November 2, 2026
Previews
Details
- Install guides
- Generates with
- Your agent's model
- Licence
- Apache-2.0
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What you get
- DESIGN_PROCEDURES.md: design procedures
- design_templates.md: design templates
- SKILL.md: workflow and checkpoints
Good fit for
- You want a miniprotein that binds a target surface
- You are looking for enzyme variants to test later in the lab
Not for
Tags
- protein design
- RFdiffusion
- ProteinMPNN
- binder
About
You say
“Design a mini-binder for this protein's interface, with sequence and validation.”
Skill published by mims-harvard under the Apache-2.0 license, delivered in its original version.
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How to use it
- Install the skill in your agent's skills folder
- Ask your agent to design a binder or therapeutic protein de novo
- Review and adjust the result
Content preview
Files
- CHECKLIST.md6.9 KB
- DESIGN_PROCEDURES.md4.1 KB
- design_templates.md3 KB
- EXAMPLES.md11.1 KB
- LICENSE11.1 KB
- NOTICE-PALATEKIT.md0.5 KB
- SKILL.md7.4 KB
- TOOLS_REFERENCE.md16.2 KB
Origin and licence
Listed unmodified
- Author
- mims-harvard
- Source
- github.com/mims-harvard/tooluniverse/tree/169d065deeb3e289b3ff36d665529a123bdad791/skills/tooluniverse-protein-therapeutic-design
- Licence
- Apache-2.0
Notice
« tooluniverse-protein-therapeutic-design » (mims-harvard, Apache-2.0) livré dans sa version d'origine : fiche en français et en anglais par PalateKit.
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