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Germline variant classification under ACMG/AMP v1.0.0
Use this resource to classify a germline variant under the ACMG/AMP criteria
New
- 309 downloads
- 147 likes
- 153 saves
Free
Install with the CLI
In a terminal, from the folder you want:
npx --yes palatekit@latest install acmg-variant-classificationWith no option, the skill goes to ~/.agents/skills/; add --agent claude-code (or codex, cursor…) to target an agent.
First time: connect the CLI with
npx --yes palatekit@latest loginThe agent normalizes the variant, collects frequencies, predictions, clinical data and functional domains, applies each criterion and combines the evidence into a verdict: pathogenic, likely pathogenic, VUS, likely benign or benign.
Mostly picked by
Updated November 2, 2026
Previews
Details
- Install guides
- Generates with
- Your agent's model
- Licence
- Apache-2.0
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What you get
- SKILL.md: ACMG/AMP criteria and evidence collection phases
- SKILL.md: five-tier verdict with cited evidence
Good fit for
- You must resolve a VUS for a clinical report
- You want to justify a classification criterion by criterion
Not for
Tags
- ACMG
- germline variant
- pathogenicity
- VUS
About
You say
“Classify this germline variant under ACMG and list the criteria triggered.”
Skill published by mims-harvard under the Apache-2.0 license, delivered in its original version.
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How to use it
- Install the skill in your agent's skills folder
- Ask your agent to classify a germline variant under the ACMG/AMP criteria
- Review and adjust the result
Content preview
Files
- LICENSE11.1 KB
- NOTICE-PALATEKIT.md0.5 KB
- SKILL.md17.6 KB
Origin and licence
Listed unmodified
- Author
- mims-harvard
- Source
- github.com/mims-harvard/tooluniverse/tree/169d065deeb3e289b3ff36d665529a123bdad791/skills/tooluniverse-acmg-variant-classification
- Licence
- Apache-2.0
Notice
« tooluniverse-acmg-variant-classification » (mims-harvard, Apache-2.0) livré dans sa version d'origine : fiche en français et en anglais par PalateKit.
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