FreeSkills
Knowledge wiki setup
- 418418 downloads
- 129129 likes
- 161161 saves
Works with
- Claude Code
- Codex
- Cursor
- and 3 more
Protein variant functional annotation v1.0.0
Use this resource to functionally annotate a protein variant with its structural and population context
New
- 353 downloads
- 203 likes
- 197 saves
Free
Install with the CLI
In a terminal, from the folder you want:
npx --yes palatekit@latest install protein-variant-functional-annotationWith no option, the skill goes to ~/.agents/skills/; add --agent claude-code (or codex, cursor…) to target an agent.
First time: connect the CLI with
npx --yes palatekit@latest loginThe agent normalizes the variant notation, runs a comprehensive annotation (FAVOR) or ProtVar, then adds gnomAD frequencies, the CADD score and gene validity. It does not produce a full ACMG classification.
Mostly picked by
Updated November 2, 2026
Previews
Details
- Install guides
- Generates with
- Your agent's model
- Licence
- Apache-2.0
Similar resources
View all- Free
FreeSkills
Wiki health check
- 552552 downloads
- 202202 likes
- 127127 saves
Works with- Claude Code
- Codex
- Cursor
- and 3 more
FreeSkills
Ask your wiki
- 374374 downloads
- 131131 likes
- 214214 saves
Works with- Claude Code
- Codex
- Cursor
- and 3 more
FreeSkills
Wiki source ingestion
- 315315 downloads
- 230230 likes
- 246246 saves
Works with- Claude Code
- Codex
- Cursor
- and 3 more
FreeSkills
Wiki auditor agent
- 556556 downloads
- 205205 likes
- 192192 saves
Works with- Claude Code
- Codex
- Cursor
- and 3 more
FreeSkills
UX research assistant
- 598598 downloads
- 142142 likes
- 236236 saves
Works with- Claude Code
- Codex
- Cursor
- and 3 more
FreeSkills
Wiki ingestion agent
- 437437 downloads
- 162162 likes
- 191191 saves
Works with- Claude Code
- Codex
- Cursor
- and 3 more
FreeSkills
Wiki librarian agent
- 304304 downloads
- 120120 likes
- 217217 saves
Works with- Claude Code
- Codex
- Cursor
- and 3 more
What you get
- SKILL.md: normalization, comprehensive annotation and structural context
- SKILL.md: frequencies, scores and evidence levels
Good fit for
- You are annotating a batch of missense variants for a pipeline
- You want a variant's protein context before an ACMG classification
Not for
Tags
- annotation
- missense
- ProtVar
- CADD
About
You say
“Annotate these missense variants with ProtVar, gnomAD and CADD.”
Skill published by mims-harvard under the Apache-2.0 license, delivered in its original version.
Show moreShow less
How to use it
- Install the skill in your agent's skills folder
- Ask your agent to functionally annotate a protein variant with its structural and population context
- Review and adjust the result
Content preview
Files
- LICENSE11.1 KB
- NOTICE-PALATEKIT.md0.5 KB
- SKILL.md14.1 KB
Origin and licence
Listed unmodified
- Author
- mims-harvard
- Source
- github.com/mims-harvard/tooluniverse/tree/169d065deeb3e289b3ff36d665529a123bdad791/skills/tooluniverse-variant-functional-annotation
- Licence
- Apache-2.0
Notice
« tooluniverse-variant-functional-annotation » (mims-harvard, Apache-2.0) livré dans sa version d'origine : fiche en français et en anglais par PalateKit.
User reviews
–
No ratings yet
Loading reviews…