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Variant mechanism from ESMC-6B SAE features v1.0.0
Use this resource to explain mechanistically why a missense variant is damaging
New
- 379 downloads
- 145 likes
- 185 saves
Free
Install with the CLI
In a terminal, from the folder you want:
npx --yes palatekit@latest install sae-feature-variant-mechanismWith no option, the skill goes to ~/.agents/skills/; add --agent claude-code (or codex, cursor…) to target an agent.
First time: connect the CLI with
npx --yes palatekit@latest loginThe agent computes protein language model features before and after the mutation, finds lost or gained features (catalytic site, binding, modification, motif) and writes an explanation. It complements pathogenicity scores without replacing them.
Mostly picked by
Updated November 2, 2026
Previews
Details
- Install guides
- Generates with
- Your agent's model
- Licence
- Apache-2.0
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What you get
- SKILL.md: input resolution and sequence construction
- SKILL.md: lost or gained features and mechanism summary
Good fit for
- AlphaMissense calls a variant damaging and you want to know why
- You want to explain a loss of function with a mechanism
Not for
Tags
- SAE
- ESMC
- mechanism
- missense
About
You say
“Why is this TP53 variant loss-of-function, according to the SAE features?”
Skill published by mims-harvard under the Apache-2.0 license, delivered in its original version.
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How to use it
- Install the skill in your agent's skills folder
- Ask your agent to explain mechanistically why a missense variant is damaging
- Review and adjust the result
Content preview
Files
- LICENSE11.1 KB
- NOTICE-PALATEKIT.md0.5 KB
- SKILL.md12.7 KB
Origin and licence
Listed unmodified
- Author
- mims-harvard
- Source
- github.com/mims-harvard/tooluniverse/tree/169d065deeb3e289b3ff36d665529a123bdad791/skills/tooluniverse-protein-sae-variant-interpretation
- Licence
- Apache-2.0
Notice
« tooluniverse-protein-sae-variant-interpretation » (mims-harvard, Apache-2.0) livré dans sa version d'origine : fiche en français et en anglais par PalateKit.
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