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From variant to biological mechanism v1.0.0
Use this resource to trace the causal chain of a variant to its consequence
New
- 439 downloads
- 225 likes
- 131 saves
Free
Install with the CLI
In a terminal, from the folder you want:
npx --yes palatekit@latest install variant-to-mechanism-analysisWith no option, the skill goes to ~/.agents/skills/; add --agent claude-code (or codex, cursor…) to target an agent.
First time: connect the CLI with
npx --yes palatekit@latest loginThe agent queries more than seven databases across three evidence layers (regulatory, molecular, disease) and builds a graded mechanistic model. It helps move from a GWAS signal to the causal gene.
Mostly picked by
Updated November 2, 2026
Previews
Details
- Install guides
- Generates with
- Your agent's model
- Licence
- Apache-2.0
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What you get
- SKILL.md: variant characterization and database queries
- SKILL.md: evidence levels and reported causal chain
Good fit for
- A GWAS signal must be linked to a causal gene
- You want to trace an eQTL to the pathway concerned
Not for
Tags
- variant
- mechanism
- GWAS
- eQTL
About
You say
“Which mechanism links the variant rs429358 to my phenotype?”
Skill published by mims-harvard under the Apache-2.0 license, delivered in its original version.
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How to use it
- Install the skill in your agent's skills folder
- Ask your agent to trace the causal chain of a variant to its consequence
- Review and adjust the result
Content preview
Files
- LICENSE11.1 KB
- NOTICE-PALATEKIT.md0.5 KB
- SKILL.md18.3 KB
Origin and licence
Listed unmodified
- Author
- mims-harvard
- Source
- github.com/mims-harvard/tooluniverse/tree/169d065deeb3e289b3ff36d665529a123bdad791/skills/tooluniverse-variant-to-mechanism
- Licence
- Apache-2.0
Notice
« tooluniverse-variant-to-mechanism » (mims-harvard, Apache-2.0) livré dans sa version d'origine : fiche en français et en anglais par PalateKit.
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